Zähringer J, Stangl E, Danninger B, Aschauer W, Motz W, Strauer B E
Medizinische Klinik I, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
J Hypertens Suppl. 1985 Dec;3(3):S493-5.
Changes in cardiac gene expression were studied during development and regression of cardiac hypertrophy in spontaneously hypertensive rats (SHR) in an attempt to determine some of the biochemical factors responsible for alterations in cardiac mass. Chronic nifedipine treatment of SHR (30 mg/kg per day for 20 weeks) led to a marked reduction in arterial blood pressure and to a subsequent regression of cardiac hypertrophy. Cardiac mRNA concentration decreased, whereas cardiac protein concentration remained unchanged. Changes in cardiac gene expression, as reflected by the decrease in cardiac mRNA concentration, were thus identified as a major factor responsible for the regression of cardiac hypertrophy after nifedipine therapy of SHR.
为了确定一些导致心脏质量改变的生化因素，研究了自发性高血压大鼠（SHR）心脏肥大发生发展及消退过程中心脏基因表达的变化。对SHR进行慢性硝苯地平治疗（每天30mg/kg，持续20周）导致动脉血压显著降低，随后心脏肥大消退。心脏mRNA浓度降低，而心脏蛋白浓度保持不变。因此，硝苯地平治疗SHR后，心脏mRNA浓度降低所反映的心脏基因表达变化被确定为心脏肥大消退的主要因素。
