Myocardial infarctions and cerebrovascular accidents in relation to blood pressure control. The IPPPSH Collaborative Group.

The International Prospective Primary Prevention Study in Hypertension (IPPPSH) was a long-term clinical trial designed to examine the effects of treatment on hypertension. It shows that in a population who at entry to the study had diastolic blood pressures of 100-125 mmHg, failure to achieve blood pressure control increases the risk of sudden death and myocardial infarction as well as stroke in both sexes and emphasizes the need to control blood pressure on a long-term basis. The absolute cardiac risk reduction associated with pressure control is greater for men than women below achieved diastolic pressures of 101-105 mmHg.