Elliott H L, Pasanisi F, Sumner D J, Reid J L
University Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
J Hypertens Suppl. 1985 Dec;3(3):S235-7.
This study investigated the effects in normotensive males of the calcium channel blockers, verapamil and nisoldipine, on the pressor responses mediated via alpha-adrenergic and non-adrenergic mechanisms. After the first doses of each drug and after 4 days continued treatment both verapamil and nisoldipine significantly attenuated the responses to angiotensin II with three- to fivefold rightward shifts of the pressor dose-response curves. Rightward shifts of comparable magnitude were obtained for phenylephrine (selective alpha 1-agonist), but with alpha-methylnoradrenaline (preferential alpha 2-agonist) only nisoldipine caused a significant twofold rightward shift and only during continued treatment. This study demonstrated that peripheral vascular adrenergic responses mediated via both alpha 1- and alpha 2-adrenoceptors in man are affected by calcium channel blocking drugs. There was no evidence that this effect was specifically linked to the alpha 2-adrenoceptor. The functional antagonism of peripheral vasopressor mechanisms was not significantly different for verapamil and nisoldipine.
本研究调查了钙通道阻滞剂维拉帕米和尼索地平对血压正常男性通过α-肾上腺素能和非肾上腺素能机制介导的升压反应的影响。在给予每种药物的首剂后以及持续治疗4天后，维拉帕米和尼索地平均显著减弱了对血管紧张素II的反应，使升压剂量-反应曲线向右移动了三至五倍。去氧肾上腺素（选择性α1-激动剂）也出现了类似幅度的右移，但对于α-甲基去甲肾上腺素（优先α2-激动剂），仅尼索地平在持续治疗期间引起了显著的两倍右移。本研究表明，人体中通过α1-和α2-肾上腺素能受体介导的外周血管肾上腺素能反应会受到钙通道阻滞剂的影响。没有证据表明这种作用与α2-肾上腺素能受体有特异性联系。维拉帕米和尼索地平对外周血管升压机制的功能性拮抗作用没有显著差异。
