Thornton Laura A, Cave Nicholas, Bridges Janis P, Stell Anneliese J
1 Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
2 Royal Veterinary College, University of London, Hatfield, UK.
J Feline Med Surg. 2018 Apr;20(4):356-361. doi: 10.1177/1098612X17710844. Epub 2017 Jun 1.
Objectives The objectives of this study were to assess owner perceptions of their cat's quality of life during treatment for lymphoma with a doxorubicin-containing multi-agent chemotherapy protocol, whether various health-related parameters correlated with quality of life scores, and to assess owner satisfaction with the protocol. Methods A postal questionnaire was sent to the owners of 33 treated cats. Owners retrospectively assessed their cat's quality of life using a Likert scale (1-10) before lymphoma was diagnosed, at diagnosis and during chemotherapy. Owners assigned scores to various health-related parameters previously reported to affect quality of life at the three time points, and correlations with quality of life scores were sought. Owners were asked to rate the importance of these health-related parameters. Satisfaction with the protocol was investigated. Results Twenty questionnaires were completed (61% response rate). The median quality of life score before diagnosis (10, range 5-10) was higher than at diagnosis (3, range 1-9) ( P <0.05). The median quality of life score during chemotherapy (7, range 3-9) was lower than before diagnosis ( P <0.05) and higher than at diagnosis, but this was not statistically significant. Quality of life scores did not correlate with individual health-related parameter scores consistently; however, quality of life scores did correlate with appetite scores during chemotherapy. Appetite, vomiting and diarrhoea were parameters perceived as important in affecting quality of life. Most owners (75%) were happy they had treated their cat. Conclusions and relevance The quality of life scores observed were comparable to a previous study using cyclophosphamide, vincristine and prednisolone, employing the same scoring system. Although quality of life scores during chemotherapy were not significantly improved at diagnosis, owner satisfaction with the protocol was high. The factors perceived by owners to determine quality of life in their pets may be different to those previously conjectured, but appetite during chemotherapy remains important.
目的 本研究的目的是评估在使用含多柔比星的多药化疗方案治疗淋巴瘤期间，猫主人对其猫咪生活质量的看法，各种与健康相关的参数是否与生活质量评分相关，以及评估主人对该方案的满意度。方法 向33只接受治疗的猫咪的主人发送了一份邮政调查问卷。主人回顾性地使用李克特量表（1 - 10）评估他们的猫咪在淋巴瘤确诊前、确诊时和化疗期间的生活质量。主人在三个时间点为先前报告的影响生活质量的各种与健康相关的参数打分，并寻找与生活质量评分的相关性。要求主人对这些与健康相关的参数的重要性进行评分。调查主人对该方案的满意度。结果 完成了20份问卷（回复率61%）。确诊前生活质量评分的中位数（10，范围5 - 10）高于确诊时（3，范围1 - 9）（P < 0.05）。化疗期间生活质量评分的中位数（7，范围3 - 9）低于确诊前（P < 0.05）且高于确诊时，但这无统计学意义。生活质量评分与各个与健康相关的参数评分并非始终相关；然而，化疗期间生活质量评分确实与食欲评分相关。食欲、呕吐和腹泻是被认为对生活质量有重要影响的参数。大多数主人（75%）对他们为猫咪进行治疗感到满意。结论及相关性 观察到的生活质量评分与先前使用环磷酰胺、长春新碱和泼尼松龙并采用相同评分系统的研究结果相当。尽管化疗期间的生活质量评分在确诊时没有显著改善，但主人对该方案的满意度很高。主人认为决定宠物生活质量的因素可能与先前推测的不同，但化疗期间的食欲仍然很重要。
