猫化疗后中性粒细胞减少伴发热。

Febrile neutropenia in cats treated with chemotherapy.

机构信息

Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Department of Clinical Studies, Oncology, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Vet Comp Oncol. 2017 Jun;15(2):550-556. doi: 10.1111/vco.12198. Epub 2016 Apr 20.

DOI:10.1111/vco.12198

PMID:27094020

Abstract

The purpose of this study was to describe the clinical presentation, potential causative agents, treatment and outcome of febrile neutropenia (FN) in chemotherapy-treated cats. Medical records from eight institutions were retrospectively reviewed. A total of 22 FN events in 20 cats were evaluated. Lymphoma was the most common cancer diagnosis; lomustine and vinca alkaloids were the most frequently implicated causative agents. Presenting clinical signs included decreased appetite, lethargy, vomiting and diarrhoea. Median body temperature and absolute neutrophil count at presentation were 104.1 °F; 40 °C (range: 103.1-105.1 °F; 39.5-40.6 °C) and 246 mL (range: 0-1600 mL ), respectively. Median number of days between chemotherapy administration and FN onset was 5 (range: 4-25 days). All but one cat were treated with intravenous fluids and broad spectrum antibiotics. Fevers resolved in all cases and absolute neutrophil counts returned to normal in 19 cats. Clinical presentation of cats with FN appears similar to that of dogs.

摘要

本研究旨在描述接受化疗的猫中性粒细胞减少性发热（FN）的临床症状、可能的病因、治疗和结局。回顾性分析了 8 家机构的病历。共评估了 20 只猫的 22 次 FN 事件。淋巴瘤是最常见的癌症诊断；洛莫司汀和长春碱类药物是最常涉及的致病药物。主要的临床表现包括食欲下降、嗜睡、呕吐和腹泻。就诊时的中位体温和绝对中性粒细胞计数分别为 104.1°F；40°C（范围：103.1-105.1°F；39.5-40.6°C）和 246 mL（范围：0-1600 mL）。化疗开始至 FN 发生的中位天数为 5 天（范围：4-25 天）。除 1 只猫外，所有猫均接受静脉输液和广谱抗生素治疗。所有猫的发热均消退，19 只猫的绝对中性粒细胞计数恢复正常。FN 猫的临床表现与犬相似。