Berkowitz R S, Alberti O, Hunter N J, Goldstein D P, Anderson D J
Gynecol Oncol. 1985 Jan;20(1):71-7. doi: 10.1016/0090-8258(85)90126-x.
Murine stage-specific embryonic antigens (SSEA-1, SSEA-3) are well characterized oncofetal antigens and have been identified in several human tumors. The current study was undertaken to determine the localization of SSEA-1 and SSEA-3 in hydatidiform mole, normal human placenta, and gestational choriocarcinoma. SSEA-3 did not react with any cellular components in hydatidiform moles, normal placentas, or choriocarcinoma cell lines. SSEA-1 was detectable in two human gestational choriocarcinoma cell lines, but not in the trophoblastic cells of 10 hydatidiform moles or in nine normal placentas between 6 weeks and term gestation. Therefore, according to this oncofetal marker system, the trophoblast in hydatidiform mole is more like normal trophoblast than gestational choriocarcinoma.
小鼠阶段特异性胚胎抗原（SSEA-1、SSEA-3）是特征明确的癌胚抗原，已在多种人类肿瘤中被鉴定出来。本研究旨在确定SSEA-1和SSEA-3在葡萄胎、正常人类胎盘和妊娠性绒毛膜癌中的定位。SSEA-3在葡萄胎、正常胎盘或绒毛膜癌细胞系中不与任何细胞成分发生反应。在两个人类妊娠性绒毛膜癌细胞系中可检测到SSEA-1，但在10例葡萄胎的滋养层细胞或妊娠6周与足月之间的9例正常胎盘中未检测到。因此，根据这个癌胚标志物系统，葡萄胎中的滋养层细胞比妊娠性绒毛膜癌更类似于正常滋养层细胞。
