Berkowitz R S, Alexander N J, Goldstein D P, Anderson D J
Gynecol Oncol. 1985 Nov;22(3):334-40. doi: 10.1016/0090-8258(85)90048-4.
The current study was undertaken to examine reactivity patterns of well-characterized anti-human sperm monoclonal antibodies with normal placenta, complete hydatidiform mole (HM), and gestational choriocarcinoma (CCA). Two anti-human sperm monoclonal antibodies (MA2 and MA7) out of a panel of 14 reacted with human CCA cell lines but did not react with the trophoblast of 4 HM or 4 normal placentas from 13 weeks to term gestation in immunofluorescence and absorption tests. Therefore, in terms of expressing these sperm-embryonic antigens, the trophoblast of HM is more like normal placental trophoblast than CCA. The relationships among normal placenta, HM, and CCA may be better understood by continued studies on the pattern of expression of additional embryonic antigens in these three gestational tissues.
本研究旨在检测特性明确的抗人精子单克隆抗体与正常胎盘、完全性葡萄胎（HM）和妊娠性绒毛膜癌（CCA）的反应模式。在一组14种抗人精子单克隆抗体中，有两种（MA2和MA7）与人类CCA细胞系发生反应，但在免疫荧光和吸收试验中，不与4例HM的滋养层细胞或13周妊娠至足月妊娠的4例正常胎盘的滋养层细胞发生反应。因此，就这些精子胚胎抗原的表达而言，HM的滋养层细胞比CCA的滋养层细胞更类似于正常胎盘滋养层细胞。通过对这三种妊娠组织中其他胚胎抗原表达模式的持续研究，可能会更好地理解正常胎盘、HM和CCA之间的关系。
