Ramadan Hassan H, McLaughlin Kevin, Josephson Gary, Rimell Frank, Bent John, Parikh Sanjay R
Allergy Rhinol (Providence). 2010 Apr 1;1(2):11. doi: 10.2500/ajra.2010.24.3431.
Balloon catheter sinuplasty (BCS) for chronic rhinosinusitis (CRS) was found to be successful in adults. The safety and feasibility of BCS in children has been recently established. The purpose of this study was to study the outcome of this technology in CRS in children.
A prospective, multicenter, nonrandomized evaluation was performed on patients with CRS. Thirty-two children between the ages of 2 and 11 years were enrolled. Safety was assessed by rate of adverse events. Effectiveness was assessed using the Sino-Nasal (SN)-5 quality-of-life questionnaire for children with CRS at 52 weeks follow-up.
Thirty-two children were enrolled of which 24 completed their 52 weeks follow-up. No adverse events were reported because of the procedure. SN-5 score improved from a mean of 4.9 at baseline to a mean of 2.95 at 52 weeks (p < 0.0001). Twelve (50%) children had a significant improvement of their SN-5 (>-1.5), 7 (29%) had moderate improvement (>-1.0 and <-1.5), 2 (8%) had mild improvement (>-0.5 and <-1.0), 1 (4%) remained the same, and 2 (8%) had worsening scores.
Balloon catheter dilation of the sinus ostia in children was safe and a significant number showed improvement of their SN-5 at 1 year follow-up. Additional studies comparing balloon sinuplasty to other modalities of treatment in children are needed to determine its efficacy in the treatment of CRS in children.
球囊导管鼻窦成形术（BCS）治疗成人慢性鼻窦炎（CRS）已获成功。最近已证实BCS在儿童中的安全性和可行性。本研究的目的是探讨该技术治疗儿童CRS的疗效。
对CRS患者进行前瞻性、多中心、非随机评估。纳入32例2至11岁的儿童。通过不良事件发生率评估安全性。在52周随访时，使用儿童CRS的鼻窦（SN）-5生活质量问卷评估有效性。
32例儿童入组，其中24例完成了52周随访。未报告因该手术导致的不良事件。SN-5评分从基线时的平均4.9分提高到52周时的平均2.95分（p < 0.0001）。12例（50%）儿童的SN-5有显著改善（> -1.5），7例（29%）有中度改善（> -1.0且< -1.5），2例（8%）有轻度改善（> -0.5且< -1.0），1例（4%）保持不变，2例（8%）评分恶化。
儿童鼻窦口球囊导管扩张术是安全的，且相当数量的儿童在1年随访时SN-5有所改善。需要进行更多研究，将球囊鼻窦成形术与儿童其他治疗方式进行比较，以确定其治疗儿童CRS的疗效。
