多发性硬化症中钆沉积导致齿状核T1高信号强度的钠磁共振成像
Sodium MRI of T1 High Signal Intensity in the Dentate Nucleus due to Gadolinium Deposition in Multiple Sclerosis.
作者信息
Eisele Philipp, Konstandin Simon, Szabo Kristina, Ong Melissa, Zöllner Frank, Schad Lothar R, Schoenberg Stefan O, Gass Achim
机构信息
Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
MR-Imaging and Spectroscopy, Faculty 01 (Physics/Electrical Engineering), University of Bremen, NW 1 Otto-Hahn-Allee 1, 28359, Bremen, Germany.
出版信息
J Neuroimaging. 2017 Jul;27(4):372-375. doi: 10.1111/jon.12448. Epub 2017 Jun 1.
BACKGROUND AND PURPOSE
Recently, several studies reported increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance imaging (MRI) as a possible consequence of multiple applications of gadolinium-based contrast agents. The aim of this study was to investigate with sodium ( Na) MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients.
METHODS
Sodium and conventional MRI were performed on a clinical 3T scanner. Total sodium concentrations (TSCs) of the DN, as well as DN-to-pons and DN-to-cerebellum SI ratios on unenhanced T1-weighted MRI were calculated.
RESULTS
A total of 18 subjects (6/18 normal controls, 12/18 MS patients [6/12 with T1 hyperintense DN]) were investigated. There was no significant difference of TSC values of the DN in MS patients with a T1-hyperintense DN (33.70 ± 2.14 mM) compared to MS patients without those signal abnormalities (33.29 ± 1.67 mM; P = .67) or to healthy controls (33.14 ± 1.12; P = .32).
CONCLUSIONS
Normal sodium signal in the T1-hyperintense DN in MS patients may point to relative tissue integrity despite gadolinium deposition in this area.
背景与目的
最近，多项研究报告称，在未增强的T1加权磁共振成像（MRI）上，齿状核（DN）的信号强度（SI）增加，这可能是多次应用钆基造影剂的结果。本研究的目的是通过钠（Na）MRI研究多发性硬化症（MS）患者齿状核可能存在的组织异常。
方法
在临床3T扫描仪上进行钠MRI和传统MRI检查。计算齿状核的总钠浓度（TSCs），以及未增强T1加权MRI上齿状核与脑桥和齿状核与小脑的SI比值。
结果
共对18名受试者进行了研究（6/18为正常对照，12/18为MS患者[6/12的齿状核T1高信号]）。与无信号异常的MS患者（33.29±1.67 mM；P = 0.67）或健康对照（33.14±1.12；P = 0.32）相比，齿状核T1高信号的MS患者的齿状核TSC值无显著差异（33.70±2.14 mM）。
结论
MS患者齿状核T1高信号中的正常钠信号可能表明尽管该区域有钆沉积，但组织相对完整。
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