a Predoctoral Researcher, Addiction Research Group, Neurosciences Research Program , IMIM-Hospital del Mar Medical Research Institute , Barcelona , Spain.
b Resident Psychiatry , Neuropsychiatry and Addiction Institute , Parc de Salut Mar, Barcelona , Spain.
J Psychoactive Drugs. 2017 Sep-Oct;49(4):297-305. doi: 10.1080/02791072.2017.1320732. Epub 2017 Jun 1.
New psychoactive tryptamines may be a public health risk since they intend to mimic the hallucinogenic effects of regulated psychoactive drugs. Few studies describe uses and clinical effects of unregulated new psychoactive tryptamines. This study aims (1) to explore the presence of tryptamines classified as NPS among the substances delivered for analysis to a harm-reduction organization; (2) to describe the substances found in the samples after analysis; and (3) to compare analytical results of regulated vs. non-regulated tryptamines. Samples delivered and analyzed by gas chromatography-mass spectrometry from 2006 to 2015 were included. A descriptive study of results was conducted. From 25,296 samples that were delivered, 436 were tryptamines; from these 232 (53.21%) were non-regulated. The most delivered non-regulated tryptamine was 4-AcO-DMT. A search of the PubMed database in July 2016 revealed that no studies in humans have ever been carried out with 4-AcO-DMT. Unregulated tryptamines likely contained one unadulterated substance (p ≤ 0.001). The number of samples submitted which contained tryptamines increased during the course of the study, with significant differences in client expectations vs. analysis results between the controlled and uncontrolled groups. There is a need for further research in order to prevent the potential health risks associated with their use.
新型精神活性色胺类物质可能对公共健康构成风险，因为它们意图模拟受管制精神活性药物的致幻作用。目前仅有少数研究描述了未经管制的新型精神活性色胺类物质的使用情况和临床效果。本研究旨在：(1) 探索在送到减少伤害组织进行分析的物质中是否存在被分类为 NPS 的色胺类物质；(2) 描述经分析后在样本中发现的物质；以及 (3) 比较管制与非管制色胺类物质的分析结果。纳入了 2006 年至 2015 年期间通过气相色谱-质谱法送检和分析的样本。对结果进行了描述性研究。在送检的 25,296 个样本中，有 436 个为色胺类物质；其中 232 个（53.21%）为非管制物质。送检的非管制色胺类物质中最常见的是 4-AcO-DMT。2016 年 7 月在 PubMed 数据库中检索发现，从未有过人类使用 4-AcO-DMT 的研究。非管制色胺类物质可能只含有一种未掺假的物质（p ≤ 0.001）。在研究过程中，送检含有色胺类物质的样本数量有所增加，在受管制和不受管制组之间，客户的期望与分析结果存在显著差异。需要进一步研究，以防止与使用这些物质相关的潜在健康风险。
