Kumar Neeraj
Continuum (Minneap Minn). 2017 Jun;23(3, Neurology of Systemic Disease):822-861. doi: 10.1212/01.CON.0000520630.69195.90.
This article provides an update on the clinical presentation and management of neurologic disease related to key nutrient deficiencies.
Major advances have been made in understanding the pathway related to vitamin B12 absorption and distribution. It is now known that deficiencies of vitamin B12 and copper have similar neurologic manifestations. Bariatric surgery is a risk factor for both. Alcoholism is just one of the many causes of thiamine deficiency. Early neurologic complications following bariatric surgery are often due to thiamine deficiency. Encephalopathy in the setting of alcoholism that persists despite thiamine replacement should prompt consideration of niacin deficiency. Pyridoxine deficiency and toxicity both have neurologic sequelae. Vitamin D deficiency and the risk for multiple sclerosis has been an area of ongoing research.
Optimal functioning of the nervous system is dependent on a constant supply of certain vitamins and nutrients. This article discusses neurologic manifestations related to deficiency of these key nutrients.
本文提供了与关键营养素缺乏相关的神经系统疾病临床表现及管理的最新进展。
在理解与维生素B12吸收和分布相关的途径方面取得了重大进展。现在已知维生素B12和铜缺乏具有相似的神经学表现。减肥手术是两者的危险因素。酗酒只是硫胺素缺乏的众多原因之一。减肥手术后早期神经并发症通常是由于硫胺素缺乏。尽管补充了硫胺素，但酗酒患者仍持续存在的脑病应促使考虑烟酸缺乏。吡哆醇缺乏和中毒均有神经后遗症。维生素D缺乏与多发性硬化症的风险一直是正在进行研究的领域。
神经系统的最佳功能依赖于某些维生素和营养素的持续供应。本文讨论了与这些关键营养素缺乏相关的神经学表现。
