Huang Y S, Horrobin D F, Manku M S, Mitchell J
Proc Soc Exp Biol Med. 1985 Jan;178(1):46-9. doi: 10.3181/00379727-178-41982.
Guinea pigs were fed regular chow diets supplemented with 5% (by weight) safflower oil, evening primrose oil, or linseed oil for 6 weeks. The unsaturated fatty acid content of these oils was 78.9% of 18:2n6, 74.1% of 18:2n6, and 9.2% of 18:3n6, or 21.5% of 18:2n6 and 46.9% of 18:3n3, respectively. In comparison with 18:2n6, dietary supplementation with 18:3n6 significantly increased the tissue levels of 18:3n6 and 20:3n6, whereas dietary 18:3n3 significantly elevated the levels of 18:3n3 in plasma and liver lipids. Dietary 18:3n3 also significantly increased 22:5n3 and 22:6n3 in total phospholipids. The tissue levels of 20:4n6, on the other hand, were not affected by either treatment. These data suggest that both delta 6- and delta 5 desaturation of n-6 fatty acids in guinea pigs are low, and that the metabolism of n-3 and n-6 fatty acids may be regulated by two different enzyme systems.
给豚鼠喂食添加了5%（按重量计）红花油、月见草油或亚麻籽油的常规饲料，持续6周。这些油中不饱和脂肪酸的含量分别为18:2n6的78.9%、18:2n6的74.1%和18:3n6的9.2%，或者分别为18:2n6的21.5%和18:3n3的46.9%。与18:2n6相比，饮食中添加18:3n6显著提高了18:3n6和20:3n6的组织水平，而饮食中添加18:3n3显著提高了血浆和肝脏脂质中18:3n3的水平。饮食中添加18:3n3还显著增加了总磷脂中22:5n3和22:6n3的含量。另一方面，两种处理均未影响20:4n6的组织水平。这些数据表明，豚鼠体内n-6脂肪酸的δ6-和δ5-去饱和作用均较低，并且n-3和n-6脂肪酸的代谢可能受两种不同酶系统的调节。
