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小主动脉根部患者采用无支架主动脉异种移植物进行全根主动脉瓣置换术。

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots.

作者信息

Tavakoli Reza, Jamshidi Peiman, Gassmann Max

机构信息

Institute of Veterinary Physiology, University of Zurich; Zurich Center of Integrative Human Physiology, University of Zurich;

Department of Cardiology, Canton Hospital Lucerne.

出版信息

J Vis Exp. 2017 May 21(123):55632. doi: 10.3791/55632.

Abstract

In patients with small aortic roots who need an aortic valve replacement with biological valve substitutes, the implantation of the stented pericardial valve might not meet the functional needs. The implantation of a too-small stented pericardial valve, leading to an effective orifice area indexed to a body surface area less than 0.85 cm/m, is regarded as prosthesis-patient mismatch (PPM). A PPM negatively affects the regression of left ventricular hypertrophy and thus the normalization of left ventricular function and the alleviation of symptoms. Persistent left ventricular hypertrophy is associated with an increased risk of arrhythmias and sudden cardiac death. In the case of predictable PPM, there are three options: 1) accept the PPM resulting from the implantation of a stented pericardial valve when comorbidities of the patient forbid the more technically demanding operative technique of implanting a larger prosthesis, 2) enlarge the aortic root to accommodate a larger stented valve substitute, or 3) implant a stentless biological valve or a homograft. Compared to classical aortic valve replacement with stented pericardial valves, the full-root implantation of stentless aortic xenografts offers the possibility of implanting a 3-4 mm larger valve in a given patient, thus allowing significant reduction in transvalvular gradients. However, a number of cardiac surgeons are reluctant to transform a classical aortic valve replacement with stented pericardial valves into the more technically challenging full-root implantation of stentless aortic xenografts. Given the potential hemodynamic advantages of stentless aortic xenografts, we have adopted full-root implantation to avoid PPM in patients with small aortic roots necessitating an aortic valve replacement. Here, we describe in detail a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses. Limitations of this technique and alternative options are discussed.

摘要

对于主动脉根部较小且需要使用生物瓣膜替代品进行主动脉瓣置换的患者,植入带支架心包瓣膜可能无法满足功能需求。植入过小的带支架心包瓣膜,导致体表面积指数化的有效瓣口面积小于0.85 cm/m²,被视为人工瓣膜-患者不匹配(PPM)。PPM会对左心室肥厚的消退产生负面影响,进而影响左心室功能的正常化和症状的缓解。持续性左心室肥厚与心律失常和心源性猝死风险增加相关。在可预测PPM的情况下,有三种选择:1)当患者的合并症不允许采用技术要求更高的植入更大假体的手术技术时,接受植入带支架心包瓣膜导致的PPM;2)扩大主动脉根部以容纳更大的带支架瓣膜替代品;3)植入无支架生物瓣膜或同种异体移植物。与使用带支架心包瓣膜进行经典主动脉瓣置换相比,无支架主动脉异种移植物的全根部植入为特定患者提供了植入大3-4毫米瓣膜的可能性,从而显著降低跨瓣压差。然而,许多心脏外科医生不愿将使用带支架心包瓣膜的经典主动脉瓣置换转变为技术要求更高的无支架主动脉异种移植物全根部植入。鉴于无支架主动脉异种移植物潜在的血流动力学优势,我们采用全根部植入以避免主动脉根部较小且需要进行主动脉瓣置换的患者出现PPM。在此,我们详细描述无支架主动脉异种移植物全根部植入技术,重点是近端缝合线和冠状动脉吻合的处理。讨论了该技术的局限性和替代方案。

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Midterm outcome after aortic root replacement with stentless porcine bioprostheses.无支架猪生物瓣主动脉根部替换术后中期结果。
Eur J Cardiothorac Surg. 2011 Aug;40(2):429-34. doi: 10.1016/j.ejcts.2010.12.010. Epub 2011 Jan 28.

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