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小主动脉根部使用无支架瓣膜进行根部置换:一项倾向评分分析。

Root replacement using stentless valves in the small aortic root: a propensity score analysis.

作者信息

Kunihara Takashi, Schmidt Kathrin, Glombitza Petra, Dzindzibadze Vachtang, Lausberg Henning, Schäfers Hans-Joachim

机构信息

Department of Thoracic and Cardiovascular Surgery, University Hospital Homburg, Homburg, Germany.

出版信息

Ann Thorac Surg. 2006 Oct;82(4):1379-84. doi: 10.1016/j.athoracsur.2006.05.021.

Abstract

BACKGROUND

Root replacement using a stentless bioprosthesis may be the optimal approach to avoid patient-prosthesis mismatch in patients with a small aortic root. Primary root replacement, however, is considered to be associated with increased surgical risk. We compared early outcome of full root replacement with a stentless bioprosthesis with that of aortic valve replacement with a stented bioprosthesis using propensity score-matching analysis.

METHODS

Of 231 patients undergoing elective, first-time aortic valve replacement with a small root (< or = 22 mm), 120 patients were selected using propensity score-matching analysis. They underwent either root replacement using a 23-mm stentless bioprosthesis (stentless group, n = 60) or supra-annular aortic valve replacement using a 21-mm stented bioprosthesis (stented group, n = 60). Preoperative characteristics and frequency of concomitant operations were identical.

RESULTS

Duration of operation (196 +/- 54 versus 174 +/- 49 minutes), cardiopulmonary bypass (112 +/- 36 versus 91 +/- 33 minutes), and aortic cross-clamping (76 +/- 21 versus 61 +/- 21 minutes) were significantly longer in the stentless group. However, the need for perioperative transfusion and the incidence of postoperative reexploration for bleeding (3% versus 8%) was lower, and ventilation time was shorter. Mean duration of intensive care and hospital stay were also significantly shorter (2.3 +/- 1.7 versus 4.0 +/- 3.9 days, 8.9 +/- 3.1 versus 12.4 +/- 5.7 days). In-hospital mortality was identical (5% each). No independent predictor for in-hospital mortality was identified.

CONCLUSIONS

Full root replacement using a stentless bioprosthesis does not increase postoperative morbidity or mortality of aortic valve replacement and may be advantageous in patients with a small aortic root.

摘要

背景

对于主动脉根部较小的患者,使用无支架生物假体进行根部置换可能是避免患者-假体不匹配的最佳方法。然而,初次根部置换被认为与手术风险增加有关。我们使用倾向评分匹配分析比较了使用无支架生物假体进行全根部置换与使用有支架生物假体进行主动脉瓣置换的早期结果。

方法

在231例接受择期首次主动脉瓣置换且根部较小(≤22mm)的患者中,通过倾向评分匹配分析选择了120例患者。他们要么使用23mm无支架生物假体进行根部置换(无支架组,n = 60),要么使用21mm有支架生物假体进行瓣环上主动脉瓣置换(有支架组,n = 60)。术前特征和同期手术频率相同。

结果

无支架组的手术时间(196±54对174±49分钟)、体外循环时间(112±36对91±33分钟)和主动脉阻断时间(76±21对61±21分钟)明显更长。然而,围手术期输血需求和术后因出血再次手术的发生率较低(3%对8%),通气时间更短。重症监护和住院时间的平均时长也明显更短(2.3±1.7对4.0±3.9天,8.9±3.1对12.4±5.7天)。住院死亡率相同(均为5%)。未发现住院死亡率的独立预测因素。

结论

使用无支架生物假体进行全根部置换不会增加主动脉瓣置换术后的发病率或死亡率,对于主动脉根部较小的患者可能具有优势。

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