Bi Mingjun, Yu Hongmei, Huang Bin, Tang Cuiyan
Department of General Surgery, The Affiliated Weihai Second Municipal Hospital of Qingdao University, 51 Guangming Road, Weihai 264200, PR China.
Department of Laboratory Medicine, The Affiliated Weihai Second Municipal Hospital of Qingdao University, 51 Guangming Road, Weihai 264200, PR China.
Gene. 2017 Aug 30;626:337-343. doi: 10.1016/j.gene.2017.05.049. Epub 2017 May 30.
Prostate cancer-associated transcript1 (PCAT-1) is a novel lncRNA that involved in cell apoptosis and proliferation of prostate cancer. However, the role of PCAT-1 on gastric cancer remains unclear. In the present study, we found that PCAT-1 was increased in gastric cancer tissues and cell lines. Over-expression of PCAT-1 was correlated with poor overall survival in gastric cancer patients. PCAT-1 knockdown through shRNA in AGS and MGC-803 cells inhibited cell proliferation, migration and invasion by regulating CDKN1A. Our data suggested that PCAT-1 could play an oncogenic role in gastric cancer progression. Silencing PCAT-1 is a potential novel therapeutic approach for gastric cancer.
前列腺癌相关转录本1（PCAT-1）是一种新型长链非编码RNA，参与前列腺癌细胞的凋亡和增殖。然而，PCAT-1在胃癌中的作用仍不清楚。在本研究中，我们发现PCAT-1在胃癌组织和细胞系中表达上调。PCAT-1的过表达与胃癌患者较差的总生存期相关。通过短发夹RNA（shRNA）敲低AGS和MGC-803细胞中的PCAT-1，可通过调节细胞周期蛋白依赖性激酶抑制剂1A（CDKN1A）抑制细胞增殖、迁移和侵袭。我们的数据表明，PCAT-1可能在胃癌进展中发挥致癌作用。沉默PCAT-1是一种潜在的胃癌新型治疗方法。
