Liu Li, Liu Yuchen, Zhuang Chengle, Xu Wen, Fu Xing, Lv Zhaojie, Wu Hanwei, Mou Lisha, Zhao Guoping, Cai Zhiming, Huang Weiren
Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Shantou University Medical College, Shantou, China.
Tumour Biol. 2015 Sep;36(10):7685-9. doi: 10.1007/s13277-015-3490-3. Epub 2015 May 2.
Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play important roles in cancer development and progression. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. We hypothesized that PCAT-1 also have roles in bladder cancer. In this study, we found that PCAT-1 was up-regulated in bladder cancer compared to paired normal urothelium. Cell proliferation inhibition and apoptosis induction were also observed in PCAT-1 small hairpin RNA (shRNA)-transfected bladder cancer T24 and 5637 cells. Our data suggest that PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer.
长链非编码RNA（lncRNAs）是一类在癌症发生和发展中起重要作用的非编码RNA。前列腺癌相关转录本1（PCAT-1）是一种新型lncRNA，可促进前列腺癌中的细胞增殖。我们推测PCAT-1在膀胱癌中也发挥作用。在本研究中，我们发现与配对的正常尿路上皮相比，PCAT-1在膀胱癌中上调。在转染了PCAT-1小发夹RNA（shRNA）的膀胱癌T24和5637细胞中也观察到细胞增殖抑制和凋亡诱导。我们的数据表明，PCAT-1发挥致癌作用，可作为治疗人类膀胱癌的治疗靶点。
