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晚期癌症患者的家庭肠外营养:有助于生存吗?

Home parenteral nutrition for advanced cancer patients: Contributes to survival?

机构信息

Department of General Intensive Care, Sackler School of Medicine, Tel Aviv University, Israel; Institute for Nutrition Research, Sackler School of Medicine, Tel Aviv University, Israel; Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel; Nursing Department, Steyer School of Health Professions, Sackler School of Medicine, Tel Aviv University, Israel.

Department of General Intensive Care, Sackler School of Medicine, Tel Aviv University, Israel; Institute for Nutrition Research, Sackler School of Medicine, Tel Aviv University, Israel; Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.

出版信息

Nutrition. 2018 Oct;54:197-200. doi: 10.1016/j.nut.2017.03.005. Epub 2017 Mar 24.

Abstract

OBJECTIVES

Patients with advanced cancer often suffer from severe malnutrition and gastrointestinal obstruction. This population could benefit from home parenteral nutrition (HPN). The aim of this study was to observe the outcome of patients with advanced cancer patients who were eligible for HPN.

METHODS

All patients in the nutrition clinic who received HPN over the past 7 y were included in the present study. We compared patients with advanced cancer with the noncancer population in terms of hospitalization rate and mortality.

RESULTS

Of 221 advanced cancer patients, 153 who had no oral/enteral intake and who received HPN survived. Of these, 35% survived for 6 mo, 27% for 1 y, 18.9% survived 2 y, and 3.9% survived for the 7 y of the follow-up. Hospitalization rate was not significantly different from the noncancer population.

CONCLUSION

These results show that HPN is a relevant palliative therapy for patients with advanced cancer patients without oral or enteral feeding access.

摘要

目的

晚期癌症患者常患有严重的营养不良和胃肠道梗阻。这类患者可能受益于家庭肠外营养(HPN)。本研究旨在观察适合 HPN 的晚期癌症患者的预后。

方法

本研究纳入了过去 7 年营养科接受 HPN 的所有患者。我们比较了晚期癌症患者与非癌症患者的住院率和死亡率。

结果

221 例晚期癌症患者中,153 例无口服/肠内摄入且接受 HPN 治疗的患者存活。其中,35%的患者存活 6 个月,27%的患者存活 1 年,18.9%的患者存活 2 年,3.9%的患者在随访的 7 年内存活。住院率与非癌症人群无显著差异。

结论

这些结果表明,对于无法经口或肠内进食的晚期癌症患者,HPN 是一种有效的姑息治疗方法。

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