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生命终末期营养治疗的伦理问题

Ethical Implications of Nutrition Therapy at the End of Life.

机构信息

Carilion Clinic, Department of Surgery, Virginia Tech Carilion School of Medicine, 1906 Belleview Ave., Roanoke, VA, 24014, USA.

Carilion Clinic Palliative Medicine, Virginia Tech Carilion School of Medicine, 1906 Belleview Ave, Roanoke, VA, 24014, USA.

出版信息

Curr Gastroenterol Rep. 2023 Mar;25(3):69-74. doi: 10.1007/s11894-023-00862-z. Epub 2023 Mar 2.

DOI:10.1007/s11894-023-00862-z
PMID:36862286
Abstract

PURPOSE OF REVIEW

Provide an evidence-based resource to inform ethically sound recommendations regarding end of life nutrition therapy.

RECENT FINDINGS

• Some patients with a reasonable performance status can temporarily benefit from medically administered nutrition and hydration(MANH) at the end of life. • MANH is contraindicated in advanced dementia. • MANH eventually becomes nonbeneficial or harmful in terms of survival, function, and comfort for all patients at end of life. • Shared decision-making is a practice based on relational autonomy, and the ethical gold standard in end of life decisions. A treatment should be offered if there is expectation of benefit, but clinicians are not obligated to offer non-beneficial treatments. A decision to proceed or not should be based on the patient's values and preferences, a discussion of all potential outcomes, prognosis for given outcomes taking into consideration disease trajectory and functional status, and physician guidance provided in the form of a recommendation.

摘要

目的综述

提供循证资源,为临终营养治疗提供合理的伦理建议。

最新发现

  1. 一些身体状况较好的患者在临终前可暂时受益于医疗提供的营养和水合(MANH)。

  2. 中晚期痴呆患者禁忌使用 MANH。

  3. 从生存、功能和临终舒适度方面来看,MANH 对所有患者最终都没有益处,甚至有害。

  4. 共享决策是一种基于关系自主权的实践,是临终决策的伦理金标准。如果有预期的获益,就应该提供治疗,但临床医生没有义务提供无益的治疗。是否继续治疗应基于患者的价值观和偏好,讨论所有潜在的结果,根据疾病轨迹和功能状态预测给定结果的预后,并以建议的形式提供医生的指导。

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本文引用的文献

1
Relational autonomy in end-of-life care ethics: a contextualized approach to real-life complexities.临终关怀伦理中的关系自主性:一种应对现实生活复杂性的情境化方法。
BMC Med Ethics. 2020 Jun 30;21(1):50. doi: 10.1186/s12910-020-00495-1.
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New perspectives on substituted relational autonomy for shared decision-making in critical care.危重病患者共享决策中替代关系自主性的新视角。
Crit Care. 2018 Oct 11;22(1):260. doi: 10.1186/s13054-018-2187-6.
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Medical Futility in Concept, Culture, and Practice.《概念、文化与实践中的医学无效性》
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Home parenteral nutrition for advanced cancer patients: Contributes to survival?晚期癌症患者的家庭肠外营养:有助于生存吗?
Nutrition. 2018 Oct;54:197-200. doi: 10.1016/j.nut.2017.03.005. Epub 2017 Mar 24.
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When Is Parenteral Nutrition Appropriate?肠外营养何时适用?
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The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis.促炎细胞因子白细胞介素18通过作用于终纹床核来调节进食。
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ESPEN guideline on ethical aspects of artificial nutrition and hydration.欧洲临床营养和代谢学会(ESPEN)关于人工营养与水化伦理问题的指南
Clin Nutr. 2016 Jun;35(3):545-56. doi: 10.1016/j.clnu.2016.02.006. Epub 2016 Feb 16.
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Nurs Ethics. 2015 Jun;22(4):440-51. doi: 10.1177/0969733014538891. Epub 2014 Aug 4.
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Home artificial nutrition in advanced cancer patients.晚期癌症患者的家庭人工营养
Tumori. 2013 Mar-Apr;99(2):218-24. doi: 10.1177/030089161309900216.
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Barriers to nutritional intake in patients with acute hip fracture: time to treat malnutrition as a disease and food as a medicine?急性髋部骨折患者营养摄入的障碍:是否应将营养不良视为一种疾病,将食物视为一种药物来进行治疗?
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