Fabes Jeremy, Matthews Lucy, Filippini Nicola, Talbot Kevin, Jenkinson Mark, Turner Martin R
Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK.
Acad Radiol. 2017 Oct;24(10):1187-1194. doi: 10.1016/j.acra.2017.04.008. Epub 2017 May 29.
T2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes.
Thirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.
Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.
FLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.
在皮质脊髓束（CST）中通过视觉评估的T2加权磁共振成像（MRI）高信号对肌萎缩侧索硬化症（ALS）的诊断缺乏敏感性。我们试图探索一种针对一系列ALS表型的液体衰减反转恢复（FLAIR）MRI强度的定量方法。
33例典型ALS患者、10例连枷臂型患者和6例原发性侧索硬化症患者在3特斯拉磁场下接受了MRI检查。对21名健康对照者以及患者表型亚组（其中一些进行了纵向研究）的CST和胼胝体中的定量FLAIR强度进行了比较。
患者组的平均FLAIR强度更高。大脑脚强度提供了最强的亚组分类。FLAIR强度呈纵向增加。CST内FLAIR的变化率与执行功能下降率和ALS功能评分相关。
FLAIR MRI编码了具有潜在诊断、分层和监测价值的可量化信息。
