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本月病例 1:接受托珠单抗治疗的患者出现急性期反应物和白细胞计数正常的脓毒性关节炎

Lesson of the month 1: Septic arthritis with normal acute phase reactants and white cell count in a patient receiving tocilizumab.

作者信息

Conway Richard, Orr Carl, McCarthy Geraldine M

机构信息

Mater Misericordiae University Hospital and CARD Newman Research Fellow, University College Dublin, Dublin, Ireland

Department of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.

出版信息

Clin Med (Lond). 2017 Jun;17(3):280-281. doi: 10.7861/clinmedicine.17-3-280.

DOI:10.7861/clinmedicine.17-3-280
PMID:28572233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6297569/
Abstract

Septic arthritis represents 8-27% of cases of monoarthritis presenting to the emergency department. Tocilizumab is an interleukin-6 blocking monoclonal antibody with the mechanistic potential to interfere with the body's normal inflammatory response to an infectious insult. We present a case of septic arthritis with a normal white cell count, C-reactive protein, erythrocyte sedimentation rate and fibrinogen in a patient treated with tocilizumab.

摘要

脓毒性关节炎占急诊科单关节炎病例的8%-27%。托珠单抗是一种白细胞介素-6阻断单克隆抗体,具有干扰机体对感染性损伤正常炎症反应的潜在机制。我们报告了1例接受托珠单抗治疗的患者,其患有脓毒性关节炎,但白细胞计数、C反应蛋白、红细胞沉降率和纤维蛋白原均正常。

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Lesson of the month 1: Septic arthritis with normal acute phase reactants and white cell count in a patient receiving tocilizumab.本月病例 1:接受托珠单抗治疗的患者出现急性期反应物和白细胞计数正常的脓毒性关节炎
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引用本文的文献

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The Effect of Tocilizumab on Inflammatory Markers in Patients Hospitalized with Serious Infections. Case Series and Review of Literature.托珠单抗对因严重感染住院患者炎症标志物的影响。病例系列及文献综述。
Life (Basel). 2021 Mar 20;11(3):258. doi: 10.3390/life11030258.
2
Pneumatosis Intestinalis and Intestinal Perforation in a Patient Receiving Tocilizumab.接受托珠单抗治疗的患者发生肠壁积气和肠穿孔
Arch Rheumatol. 2018 Jan 17;33(3):372-375. doi: 10.5606/ArchRheumatol.2018.6668. eCollection 2018 Sep.

本文引用的文献

1
Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials.托法替布与生物性改善病情抗风湿药治疗类风湿关节炎临床试验中严重感染的系统评价和荟萃分析
Arthritis Res Ther. 2015 Dec 15;17:362. doi: 10.1186/s13075-015-0880-2.
2
IL-6 polymorphisms: a useful genetic tool for inflammation research?白细胞介素 6 多态性:炎症研究的有用遗传工具?
J Clin Invest. 2013 Apr;123(4):1413-4. doi: 10.1172/JCI67221. Epub 2013 Apr 1.
3
Interleukin-6: from an inflammatory marker to a target for inflammatory diseases.白细胞介素-6:从炎症标志物到炎症性疾病的治疗靶点。
Trends Immunol. 2012 Nov;33(11):571-7. doi: 10.1016/j.it.2012.07.003. Epub 2012 Aug 8.