Mestres Ivan, Sung Ching-Hwa
DFG-Research Center for Regenerative Therapies, Cluster of Excellence, TU Dresden, Dresden, Germany.
Department of Ophthalmology, Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY, USA.
Neurogenesis (Austin). 2017 Apr 27;4(1):e1316887. doi: 10.1080/23262133.2017.1316887. eCollection 2017.
Accumulating findings have begun to unveil the important role of the endosomal machinery in the nervous system development. Endosomes have been linked to the differential segregation of cell fate determining molecules in asymmetrically dividing progenitors during neurogenesis. Additionally, the precise removal and reinsertion of membrane components through endocytic trafficking regulates the spatial and temporal distribution of signaling receptors and adhesion molecules, which determine the morphology and motility of migrating neurons. Emerging evidence suggests that the role of the endosomal sorting adaptors is dependent upon cell type and developmental stage. The repertoire of the signaling receptors and/or adhesion molecules sorted by the endosome during these processes remains to be explored. In this commentary, we will briefly address the progress in this research field.
越来越多的研究结果开始揭示内体机制在神经系统发育中的重要作用。在内神经发生过程中，内体与不对称分裂祖细胞中细胞命运决定分子的差异分离有关。此外，通过内吞运输精确去除和重新插入膜成分，可调节信号受体和黏附分子的时空分布，而这些分子决定了迁移神经元的形态和运动能力。新出现的证据表明，内体分选衔接蛋白的作用取决于细胞类型和发育阶段。在这些过程中，由内体分选的信号受体和/或黏附分子的种类仍有待探索。在本评论中，我们将简要介绍这一研究领域的进展。
