Wu Meng-Ju, Chang Chun-Ju
Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana, USA.
Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Bio Protoc. 2016 Jul 5;6(13). doi: 10.21769/BioProtoc.1852.
Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and chemically induced tumors. To study the complex interaction between the mammary epithelia and the microenvironment, with a focus on the mechanism underlying the role obesity plays in the regulation of the cancer stem cell traits and the development of mammary cancer , we have established a diet-induced obesity (DIO) rat model of breast cancer (Chang ., 2015).
肥胖与乳腺癌进展有关，但其潜在机制仍不清楚。女性在被诊断患有乳腺癌时超重或肥胖与复发风险高有关，而与治疗因素无关。在啮齿动物中，高体重也与自发性和化学诱导性肿瘤的发病率增加有关。为了研究乳腺上皮细胞与微环境之间的复杂相互作用，重点关注肥胖在调节癌症干细胞特性和乳腺癌发展中所起作用的潜在机制，我们建立了饮食诱导肥胖（DIO）大鼠乳腺癌模型（Chang等，2015年）。
