Fuchs-Buder T, Schmartz D
Département d'Anesthésie-Réanimation, CHU de Nancy, Hopitaux de Brabois, 4, Rue du Morvan, 54511, Vandoeuvres-Les-Nancy, Frankreich.
Anaesthesist. 2017 Jun;66(6):465-476. doi: 10.1007/s00101-017-0325-1.
Even small degrees of residual neuromuscular blockade, i. e. a train-of-four (TOF) ratio >0.6, may lead to clinically relevant consequences for the patient. Especially upper airway integrity and the ability to swallow may still be markedly impaired. Moreover, increasing evidence suggests that residual neuromuscular blockade may affect postoperative outcome of patients. The incidence of these small degrees of residual blockade is relatively high and may persist for more than 90 min after a single intubating dose of an intermediately acting neuromuscular blocking agent, such as rocuronium and atracurium. Both neuromuscular monitoring and pharmacological reversal are key elements for the prevention of postoperative residual blockade.
即使是轻度的残余神经肌肉阻滞,即四个成串刺激(TOF)比值>0.6,也可能给患者带来临床相关后果。尤其是上呼吸道完整性和吞咽能力可能仍会受到明显损害。此外,越来越多的证据表明,残余神经肌肉阻滞可能影响患者的术后转归。这些轻度残余阻滞的发生率相对较高,在单次给予中效神经肌肉阻滞剂(如罗库溴铵和阿曲库铵)进行插管剂量后,可能持续超过90分钟。神经肌肉监测和药物逆转都是预防术后残余阻滞的关键因素。