Zaimy M A, Saffarzadeh N, Mohammadi A, Pourghadamyari H, Izadi P, Sarli A, Moghaddam L K, Paschepari S R, Azizi H, Torkamandi S, Tavakkoly-Bazzaz J
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Center of Excellence for Biodiversity, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Cancer Gene Ther. 2017 Jun;24(6):233-243. doi: 10.1038/cgt.2017.16. Epub 2017 Jun 2.
Cancer is one of the leading cause of death in the world with the prevalence of >10 million mortalities annually. Current cancer treatments include surgical intervention, radiation, and taking chemotherapeutic drugs, which often kill the healthy cells and result in toxicity in patients. Therefore, researchers are looking for ways to be able to eliminate just cancerous cells. Intra-tumor heterogeneity of cancerous cells is the main obstacle on the way of an effective cancer treatment. However, better comprehension of molecular basis of tumor and the advent of new diagnostic technologies can help to improve the treatment of various cancers. Therefore, study of epigenetic changes, gene expression of cancerous cells and employing methods that enable us to correct or minimize these changes is critically important. In this paper, we will review the recent advanced strategies being used in the field of cancer research.
癌症是全球主要死因之一，每年有超过1000万人死亡。目前的癌症治疗方法包括手术干预、放疗和服用化疗药物，这些方法常常会杀死健康细胞并给患者带来毒性。因此，研究人员正在寻找能够只消灭癌细胞的方法。癌细胞的肿瘤内异质性是有效治疗癌症道路上的主要障碍。然而，对肿瘤分子基础的更好理解以及新诊断技术的出现有助于改善各种癌症的治疗。因此，研究表观遗传变化、癌细胞的基因表达并采用能够纠正或最小化这些变化的方法至关重要。在本文中，我们将综述癌症研究领域目前正在使用的最新先进策略。
