Johagen Daniel, Svenmarker Pontus, Jonsson Per, Svenmarker Staffan
Department of Public Health and Clinical Medicine, Heart Centre, Umeå University, Umeå - Sweden.
Department of Physics, Umeå University, Umeå - Sweden.
Int J Artif Organs. 2017 Sep 15;40(9):498-502. doi: 10.5301/ijao.5000602. Epub 2017 May 23.
The aim of this study was to investigate the filtration efficacy of a 38-µm 1-layer screen filter based on Doppler registrations and video recordings of gaseous microbubbles (GME) observed in a microscope.
The relative filtration efficacy (RFE) was calculated from 20 (n = 20) sequential bursts of air introduced into the Plasmodex® primed test circuit.
The main findings indicate that the RFE decreased (p = 0.00), with increasing flow rates (100-300 mL/min) through the filter screen. This reaction was most accentuated for GME below the size of 100 µm, where counts of GME paradoxically increased after filtration, indicating GME fragmentation. For GME sized between 100-250 µm, the RFE was constantly >60%, independently of the flow rate level. The video recording documenting the GME interactions with the screen filter confirmed the experimental findings.
The 38-µm 1-layer screen filter investigated in this experimental setup was unable to trap gaseous microbubbles effectively, especially for GME below 100 µm in size and in conjunction with high flow rates.
本研究旨在基于在显微镜下观察到的气态微泡（GME）的多普勒记录和视频记录，研究一种38微米单层筛网过滤器的过滤效果。
通过向Plasmodex®预充测试回路中依次引入20次（n = 20）空气脉冲来计算相对过滤效果（RFE）。
主要研究结果表明，随着通过滤网的流速增加（100 - 300毫升/分钟），RFE降低（p = 0.00）。对于尺寸小于100微米的GME，这种反应最为明显，过滤后GME的数量反而增加，表明GME发生了破碎。对于尺寸在100 - 250微米之间的GME，RFE始终>60%，与流速水平无关。记录GME与筛网过滤器相互作用的视频记录证实了实验结果。
在此实验装置中研究的38微米单层筛网过滤器无法有效捕获气态微泡，特别是对于尺寸小于100微米且流速较高的GME。
