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文拉法辛中毒并发应激性心肌病：成功应用体外生命支持、静脉注射脂质乳剂和CytoSorb®。

Venlafaxine intoxication with development of takotsubo cardiomyopathy: successful use of extracorporeal life support, intravenous lipid emulsion and CytoSorb®.

作者信息

Schroeder Ines, Zoller Michael, Angstwurm Matthias, Kur Felix, Frey Lorenz

机构信息

Department of Anesthesiology, University Hospital Ludwig-Maximilians (LMU) University of Munich, Munich - Germany.

Department of Internal Medicine I, University Hospital Ludwig-Maximilians (LMU) University of Munich, Munich - Germany.

出版信息

Int J Artif Organs. 2017 Jul 5;40(7):358-360. doi: 10.5301/ijao.5000595. Epub 2017 May 23.

DOI:10.5301/ijao.5000595
PMID:28574114
Abstract

We describe a young patient who ingested 18 g (240 times the daily therapeutic dose) of venlafaxine in a suicide attempt. She developed severe cardiomyopathy in a takotsubo distribution causing cardiogenic shock and multi-organ dysfunction syndrome (MODS). She was successfully treated with intravenous lipid emulsion (ILE), extracorporeal life support (ECLS) and CytoSorb®. This is remarkable as, to the best of the authors' knowledge, this is the highest amount of venlafaxine intake seen in the literature with a nonfatal outcome.

摘要

我们描述了一名年轻患者，其在自杀企图中摄入了18克（每日治疗剂量的240倍）文拉法辛。她出现了应激性心肌病，呈章鱼壶样分布，导致心源性休克和多器官功能障碍综合征（MODS）。她通过静脉注射脂质乳剂（ILE）、体外生命支持（ECLS）和CytoSorb®成功得到治疗。值得注意的是，据作者所知，这是文献中报道的非致命性文拉法辛摄入量最高的案例。

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