Born B, Hoffer E, Fraipont V, Joachim S, Gougnard T, Minon J M
) Service de Cardiologie, CHU Liège, Belgique.
Service de Cardiologie, CHR Citadelle, Liège, Belgique.
Rev Med Liege. 2020 Nov;75(11):699-702.
Venlafaxine is a widely prescribed antidepressant drug acting as a reuptake inhibitor of serotonin and noradrenaline. An overdose of venlafaxine can cause cardiovascular toxicity and cardiogenic shock can occur. A 32-year-old man ingested 12g of sustained-release venlafaxine in a suicidal attempt and developed within 24h acute heart failure with refractory cardiogenic shock requiring support by ECMO. The blood toxicology showed persistence of high levels of venlafaxine at day 10. The patient fully recovered and showed normal cardiac function at 3-months follow-up.
文拉法辛是一种广泛使用的抗抑郁药物，作为5-羟色胺和去甲肾上腺素的再摄取抑制剂。过量服用文拉法辛可导致心血管毒性，并可能发生心源性休克。一名32岁男子为自杀而服用了12克缓释文拉法辛，在24小时内出现急性心力衰竭和难治性心源性休克，需要体外膜肺氧合（ECMO）支持。血液毒理学显示，在第10天时文拉法辛水平持续偏高。患者完全康复，在3个月的随访中显示心脏功能正常。
