Department of Chemical Engineering, McMaster University , Hamilton, Canada L8S 4L7.
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
Langmuir. 2017 Jun 20;33(24):6108-6115. doi: 10.1021/acs.langmuir.7b01092. Epub 2017 Jun 8.
Microcapsules enabling precise delivery and controlled release are highly desirable. However, it is still challenging to control the release profile by regulating the microcapsule shell permeability. In this work, gas-switchable microgel colloidosome (MGC) with oxygen (O) and carbon dioxide (CO) dual gas-tunable shell permeability has been developed and tested for control release of water-soluble cargo molecules, based on the size exclusion mechanism. The O and CO dual gas-switchable poly(2-(diethylamino)ethyl methacrylate-co-2,3,4,5,6-pentafluorostyrene), P(DEA-co-FS), microgels having surface modified with amino group (-NH) were synthesized and used to stabilize oil-in-water (O/W) Pickering emulsions. The oil-soluble poly(propylene glycol) diglycidyl ether (PPGDGE) was added as an intermicrogel cross-linker. The cross-linking between adjacent microgel particles at the water-oil interface was achieved through the amine-epoxy reaction of PPGDGE with the amine groups at the particle surface. Fluorescent-labeled dextran model cargo molecules of 10 kDa (D) and 2000 kDa (D) were uploaded under CO treatment and locked inside the MGC with N treatment. The O and CO dual-gas switchable properties offered the MGC with tunable shell permeability, which allowed the hierarchical release of D and D based on size exclusive mechanism. This work provides a robust method for preparation of gas-switchable microcapsules with tunable permeability and size-exclusive hierarchical release profile, promising for multiple ingredient controllable release, separation, and reaction.
微胶囊能够实现精确的传递和控制释放，因此备受关注。然而，通过调节微胶囊壳的渗透性来控制释放特性仍然具有挑战性。在这项工作中，基于尺寸排阻机制，我们开发并测试了具有氧气（O）和二氧化碳（CO）双气可调渗透性的气致变色微凝胶胶体（MGC），用于控制水溶性货物分子的释放。合成了表面带有氨基（-NH）的氧（O）和二氧化碳（CO）双气可调聚[2-（二乙基氨基）乙基甲基丙烯酸酯-co-2,3,4,5,6-五氟苯乙烯]（P（DEA-co-FS）微凝胶，并用于稳定油包水（O/W）Pickering 乳液。添加油溶性聚丙二醇二缩水甘油醚（PPGDGE）作为内微凝胶交联剂。通过 PPGDGE 与颗粒表面上的氨基之间的胺-环氧反应，在油水界面处实现相邻微凝胶颗粒之间的交联。将荧光标记的 10 kDa（D）和 2000 kDa（D）的葡聚糖模型货物分子加载到 CO 处理下，并在 N 处理下将其锁定在 MGC 内。O 和 CO 双气开关特性为 MGC 提供了可调的壳渗透性，这允许基于尺寸排阻机制对 D 和 D 进行分级释放。这项工作为制备具有可调渗透性和尺寸排阻分级释放特性的气致变色微胶囊提供了一种稳健的方法，有望用于多种成分的可控释放、分离和反应。
