Macdonald Η Μ, Nettlefold L, Maan E J, Côté H, Alimenti A
Department of Family Practice, University of British Columbia, Vancouver, Canada.
J Musculoskelet Neuronal Interact. 2017 Jun 1;17(2):27-37.
To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected (HUU) youth.
We assessed muscle power (relative to body mass, P/mass), muscle force normalized to body weight (F/BW), force efficiency, jump height (H) and velocity (V) during a single two-legged jump with hands on waist on a force platform (Leonardo) in HIV+ youth (n=35, 9-21 y). Thirty-three and 22 participants returned at 12- and 24-months, respectively. We compared age- and sex-specific z-scores in the HIV+ youth to those in HUU controls (n=716, 9-21 y) adjusting for height and muscle cross-sectional area (MCSA, by pQCT).
At baseline, z-scores for Pmax/mass, F/BW and V were less than 1 standard deviation lower than HUU after adjusting for height and MCSA (p⟨0.05). P/mass z-score was negatively associated with level of immunosuppression (p=0.013), but this relationship was not significant after adjusting for height and MCSA (p=0.07). Z-scores for all mechanography outcomes remained stable over time in HIV+ youth.
Small deficits in muscle power were apparent in children and youth who acquired HIV perinatally, and the trajectory of muscle power did not change over two years. Further study is needed to identify effective strategies to improve dynamic muscle function in this population.
比较围产期感染艾滋病毒的青少年与未接触艾滋病毒且未受感染（HUU）的青少年之间的肌肉力量。
我们在力平台（莱昂纳多）上对35名年龄在9至21岁的艾滋病毒阳性青少年进行单腿双手叉腰跳跃时，评估了他们的肌肉力量（相对于体重，P/质量）、体重标准化肌肉力量（F/BW）、力量效率、跳跃高度（H）和速度（V）。分别有33名和22名参与者在12个月和24个月时返回。我们将艾滋病毒阳性青少年中按年龄和性别划分的z分数与HUU对照组（716名，9至21岁）中经身高和肌肉横截面积（MCSA，通过pQCT测量）调整后的z分数进行比较。
在基线时，经身高和MCSA调整后，Pmax/质量、F/BW和V的z分数比HUU低不到1个标准差（p<0.05）。P/质量z分数与免疫抑制水平呈负相关（p = 0.013），但在经身高和MCSA调整后，这种关系不显著（p = 0.07）。艾滋病毒阳性青少年中所有力学测量结果的z分数随时间保持稳定。
围产期感染艾滋病毒的儿童和青少年存在明显的肌肉力量小缺陷，且肌肉力量轨迹在两年内没有变化。需要进一步研究以确定改善该人群动态肌肉功能的有效策略。
