Han Zhenyan, Yin Yuzhu, Zhang Yuan, Ehrhardt Stephan, Thio Chloe L, Nelson Kenrad E, Bai Xiaoyi, Hou Hongying
Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.
PLoS One. 2017 Jun 2;12(6):e0178671. doi: 10.1371/journal.pone.0178671. eCollection 2017.
Hepatitis B virus (HBV) infection remains a serious public health problem worldwide. Mother-to-child transmission (MTCT) of HBV is the major mode of transmission in HBV-endemic areas, including China, where little is known about pregnant women's knowledge of and attitudes towards HBV infection and MTCT.
A cross-sectional survey, conducted in pregnant women in Guangdong Province, China, measured HBV knowledge and attitudes using a questionnaire, at one tertiary and two rural hospitals.
The total response rate was 94.5% (737/780). Of the 11 knowledge questions, the mean score was 6.73 ± 3.04 (mean ± SD). Most pertinent to preventing MTCT, 53.3% of the respondents did not know that HBV can be transmitted through unprotected sexual intercourse and nearly 20% did not know that HBV can be transmitted from mother to infant. The results of the four attitude questions was better with 83% and 85% being willing to be screened for HBV and let their baby receive HBV vaccine and HBIg, respectively. However, only 16.5% of respondents agreed that they would be willing to take drugs that are known not to harm the fetus to prevent MTCT of HBV. In multivariable analysis, higher education level was associated with better knowledge and attitude scores.
Knowledge about HBV among pregnant women was poor and needs to be improved to prevent MTCT of HBV. Health education needs to be directed towards pregnant mothers, particularly less educated mothers, in high HBV endemicity settings.
乙型肝炎病毒（HBV）感染仍是全球严重的公共卫生问题。HBV母婴传播（MTCT）是包括中国在内的HBV流行地区的主要传播方式，而对于孕妇对HBV感染及MTCT的知晓情况和态度了解甚少。
在中国广东省的孕妇中开展了一项横断面调查，在一家三级医院和两家乡村医院使用问卷测量孕妇的HBV知识和态度。
总应答率为94.5%（737/780）。在11个知识问题中，平均得分为6.73±3.04（均值±标准差）。与预防MTCT最为相关的是，53.3%的受访者不知道HBV可通过无保护性行为传播，近20%的受访者不知道HBV可母婴传播。四个态度问题的结果较好，分别有83%和85%的受访者愿意接受HBV筛查并让其婴儿接种HBV疫苗和乙肝免疫球蛋白（HBIg）。然而，只有16.5%的受访者表示愿意服用已知对胎儿无害的药物来预防HBV的MTCT。在多变量分析中，较高的教育水平与更好的知识和态度得分相关。
孕妇对HBV的知识掌握较差，需要加以改善以预防HBV的MTCT。在HBV高流行地区，需要针对孕妇，尤其是受教育程度较低的孕妇开展健康教育。
