万古霉素逐渐减量与复发性艰难梭菌感染患者粪菌移植失败的风险。
Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection.
机构信息
Division of Infectious Diseases.
Department of Internal Medicine.
出版信息
Clin Infect Dis. 2017 Oct 1;65(7):1214-1217. doi: 10.1093/cid/cix511.
PMID:28575220
Abstract
We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).
摘要
我们回顾性分析了 2011 年至 2014 年在一家三级转诊中心接受粪菌移植（FMT）治疗复发性艰难梭菌感染的 109 例患者的队列，以确定 FMT 失败的危险因素。在多变量分析中，FMT 前未使用口服万古霉素逐渐减量与 FMT 失败的显著风险相关（比值比，0.15；95%置信区间，0.007-0.40）。
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