透视PERCH研究：它能让我们了解儿童肺炎病因的哪些方面？
PERCH in Perspective: What Can It Teach Us About Pneumonia Etiology in Children?
作者信息
Klugman Keith P, Rodgers Gail L
机构信息
Bill & Melinda Gates Foundation, Seattle, Washington.
出版信息
Clin Infect Dis. 2017 Jun 15;64(suppl_3):S185-S187. doi: 10.1093/cid/cix075.
Abstract
The pneumonia team at the Bill & Melinda Gates Foundation congratulates the Pneumonia Etiology Research for Child Health (PERCH) study on delivering on their grant to collect high-quality data from thousands of children with World Health Organization-defined severe and very severe pneumonia and from controls in 9 diverse sites in 7 low- and middle-income countries. This supplement sets the foundation to understanding this complex study by providing an in-depth description of the study methodology, including discussion of key aspects such as antibiotic pretreatment, chest radiograph interpretation, utility of induced sputum in children, measurement of pathogen density, and use of C-reactive protein, and how these affect pneumonia etiology.
摘要
比尔及梅琳达·盖茨基金会的肺炎研究团队祝贺儿童健康肺炎病因研究（PERCH）项目成功完成资助任务，该项目从7个低收入和中等收入国家的9个不同地点的数千名患有世界卫生组织定义的重度和极重度肺炎的儿童以及对照组中收集了高质量数据。本增刊通过深入描述研究方法，包括讨论抗生素预处理、胸部X光片解读、儿童诱导痰的效用、病原体密度测量、C反应蛋白的使用等关键方面，以及这些因素如何影响肺炎病因，为理解这项复杂的研究奠定了基础。
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