Vnukov V V, Sidorov R V, Milutina N P, Ananyan A A, Gvaldin D Yu, Sagakyants A B, Shlyk I F, Talalaev E P
Southern Federal University, Rostov-on-Don, 344006, Russian Federation;
Rostov State Medical University, Rostov-on-Don, 344022, Russian Federation.
Adv Gerontol. 2017;30(2):269-275.
76 patients with coronary heart disease (who had undergone coronary artery bypass grafting) were examined to investigate the role of pro-inflammatory cytokines and enzymes involved in redox regulation, in the mechanisms of development of systemic inflammatory response syndrome. Patients were divided into 2 groups: 1st - patients with coronary heart disease, who as a result of clinical trials has not been set postpericardiotomy syndrome; 2nd - patients with coronary heart disease who have been diagnosed postpericardiotomy syndrome. The blood plasma of both groups indicated intensification of production of interleukin-6, intrleukin-8, as well as - an imbalance in the peroxiredoxin-1 and glutathione peroxidase. These changes by patients with postpericardiotomy syndrome are observed at the earliest time and differed depth of expression. The results of this work confirm the high potential of the investigated indicators for prevention and monitoring postpericardiotomy syndrome development.
对76例冠心病患者（已接受冠状动脉搭桥术）进行检查，以研究促炎细胞因子和参与氧化还原调节的酶在全身炎症反应综合征发生机制中的作用。患者分为2组：第1组为冠心病患者，其临床试验结果未发现心包切开术后综合征；第2组为已诊断为心包切开术后综合征的冠心病患者。两组患者的血浆均显示白细胞介素-6、白细胞介素-8的产生增加，以及过氧化物酶1和谷胱甘肽过氧化物酶失衡。心包切开术后综合征患者最早观察到这些变化，且表达深度不同。这项工作的结果证实了所研究指标在预防和监测心包切开术后综合征发展方面的巨大潜力。
