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核糖体回收和再起始的 ABC(E1)

The ABC(E1)s of Ribosome Recycling and Reinitiation.

机构信息

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Mol Cell. 2017 Jun 1;66(5):578-580. doi: 10.1016/j.molcel.2017.05.017.

DOI:10.1016/j.molcel.2017.05.017
PMID:28575655
Abstract

In a recent issue of Nature Structural & Molecular Biology, Heuer et al. (2017) present a 3.9-Å cryo-EM structure of the 40S:ABCE1 post-splitting complex. This structure provides new insights into a dual role for ABCE1 in translation recycling and reinitiation and revisits the interpretation of Simonetti et al. (2016).

摘要

在最近一期的《自然结构与分子生物学》杂志上,Heuer 等人(2017)呈现了一个 3.9Å 的 cryo-EM 结构,该结构为 40S:ABCE1 分裂后复合物。这个结构为 ABCE1 在翻译循环和再起始中的双重作用提供了新的见解,并重新审视了 Simonetti 等人(2016)的解释。

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