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采用电子束技术对Ti6Al4V合金进行创新表面改性以用于生物医学应用。

Innovative surface modification of Ti6Al4V alloy by electron beam technique for biomedical application.

作者信息

Ramskogler Claudia, Warchomicka Fernando, Mostofi Sepideh, Weinberg Annelie, Sommitsch Christof

机构信息

Institute of Materials Science, Joining and Forming, Graz University of Technology, Kopernikusgasse 24, 8010 Graz, Austria.

Institute of Materials Science, Joining and Forming, Graz University of Technology, Kopernikusgasse 24, 8010 Graz, Austria.

出版信息

Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:105-113. doi: 10.1016/j.msec.2017.03.311. Epub 2017 Apr 11.

Abstract

The low elastic modulus, high corrosion resistance and excellent biological response allow titanium alloys to be used for permanent orthopaedic devices. Furthermore, the design of specific multi scale surface topographies on titanium alloys can provide a fast osseointegration. This work highlights the use of electron beam as a promising technique to produce a designed surface topography and improve the tribological behaviour of Ti6Al4V alloy. The produced surface topography due to the transport of molten material is influenced by the deflection figure, the physical properties of the material and the energy input. The analysis of the surface roughness shows an increment of the area up to 26% and a canal shape in a range from 1.3μm up to 9μm depth and from 68.6μm up to 119.7μm width. The high solidification rate reached during the process affects the microstructure, provoking the formation of martensite and thus the improvement of hardness. In vitro studies with pre-osteoblastic MC3T3-E1 cells performed for several cultivation times show the cells with a polygonal shape and built connections through elongated filopodia. A notable increase of cell spreading area on surface structure with a finer canal shape is found after 48h cultivation time.

摘要

低弹性模量、高耐腐蚀性和出色的生物反应特性使得钛合金可用于永久性骨科器械。此外,在钛合金上设计特定的多尺度表面形貌能够实现快速骨整合。这项工作突出了电子束作为一种有前景的技术,可用于制造设计好的表面形貌并改善Ti6Al4V合金的摩擦学性能。由于熔融材料的迁移而产生的表面形貌受偏转图形、材料的物理性能和能量输入的影响。表面粗糙度分析表明,面积增加了26%,形成了深度在1.3μm至9μm、宽度在68.6μm至119.7μm范围内的沟槽形状。该过程中达到的高凝固速率影响了微观结构,促使马氏体形成,从而提高了硬度。对前成骨细胞MC3T3-E1进行的体外研究在多个培养时间点进行,结果显示细胞呈多边形,并通过细长的丝状伪足建立连接。培养48小时后,发现细胞在具有更细沟槽形状的表面结构上的铺展面积显著增加。

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