Gordin D M, Ion R, Vasilescu C, Drob S I, Cimpean A, Gloriant T
Institut des Sciences Chimiques de Rennes (UMR CNRS 6226), INSA Rennes, 20 Avenue des Buttes de Coësmes, F-35043 Rennes Cedex, France.
University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania.
Mater Sci Eng C Mater Biol Appl. 2014 Nov;44:362-70. doi: 10.1016/j.msec.2014.08.003. Epub 2014 Aug 7.
In this study, the "Gum Metal" titanium-based alloy (Ti-23Nb-0.7Ta-2Zr-1.2O) was synthesized by melting and then characterized in order to evaluate its potential for biomedical applications. Thus, the mechanical properties, the corrosion resistance in simulated body fluid and the in vitro cell response were investigated. It was shown that this alloy presents a very high strength, a low Young's modulus and a high recoverable strain by comparison with the titanium alloys currently used in medicine. On the other hand, all electrochemical and corrosion parameters exhibited more favorable values showing a nobler behavior and negligible toxicity in comparison with the commercially pure Ti taken as reference. Furthermore, the biocompatibility tests showed that this alloy induced an excellent response of MC3T3-E1 pre-osteoblasts in terms of attachment, spreading, viability, proliferation and differentiation. Consequently, the "Gum Metal" titanium-based alloy processes useful characteristics for the manufacturing of highly biocompatible medical devices.
在本研究中，通过熔炼合成了“牙龈金属”钛基合金（Ti-23Nb-0.7Ta-2Zr-1.2O），然后对其进行表征，以评估其在生物医学应用方面的潜力。因此，研究了其力学性能、在模拟体液中的耐腐蚀性以及体外细胞反应。结果表明，与目前医学上使用的钛合金相比，该合金具有非常高的强度、低杨氏模量和高可恢复应变。另一方面，与作为参考的商业纯钛相比，所有电化学和腐蚀参数均显示出更有利的值，表明其具有更惰性的行为和可忽略不计的毒性。此外，生物相容性测试表明，该合金在附着、铺展、活力、增殖和分化方面对MC3T3-E1前成骨细胞具有优异的反应。因此，“牙龈金属”钛基合金具有用于制造高生物相容性医疗设备的有用特性。
