Haeffner-Cavaillon N, Cavaillon J M, Etievant M, Lebbar S, Szabo L
Cell Immunol. 1985 Mar;91(1):119-31. doi: 10.1016/0008-8749(85)90037-1.
Specific binding of Bordetella pertussis and Neisseria meningitidis endotoxins to human monocytes and murine macrophages was demonstrated. Binding of B. pertussis endotoxin could be inhibited by endotoxins of Salmonella minnesota, Escherichia coli, and Klebsiella pneumoniae, the extent of inhibition being dependent on the origin of the lipopolysaccharides and on the origin of the mononuclear phagocytic cells. The binding of B. pertussis and N. meningitidis endotoxins which was mediated by the polysaccharide region of the endotoxins was serum dependent. The results indicated that the binding of endotoxin was promoted neither by natural antibodies directed against the endotoxin nor by proteins known to combine with endotoxins: immunoglobulins, albumin, or fibronectin; we have provided some evidence that complement components may play a role in the specific binding of endotoxins to the monocyte/macrophage membrane.
已证实百日咳博德特氏菌和脑膜炎奈瑟氏菌内毒素与人单核细胞及小鼠巨噬细胞存在特异性结合。明尼苏达沙门氏菌、大肠杆菌和肺炎克雷伯氏菌的内毒素可抑制百日咳博德特氏菌内毒素的结合，抑制程度取决于脂多糖的来源及单核吞噬细胞的来源。百日咳博德特氏菌和脑膜炎奈瑟氏菌内毒素由内毒素多糖区域介导的结合依赖于血清。结果表明，针对内毒素的天然抗体或已知与内毒素结合的蛋白质（免疫球蛋白、白蛋白或纤连蛋白）均不会促进内毒素的结合；我们已提供一些证据表明补体成分可能在内毒素与单核细胞/巨噬细胞膜的特异性结合中发挥作用。
