Wang Xin, Li Chang, Fan Na, Li Jing, He Zhonggui, Sun Jin
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:370-375. doi: 10.1016/j.msec.2017.04.060. Epub 2017 Apr 17.
The purpose of this study was to develop amino modified multimodal nanoporous silica nanoparticles (M-NSNs-NH) loaded with doxorubicin hydrochloride (DOX), intended to enhance the drug loading capacity and to achieve controlled release effect. M-NSNs were functionalized with aminopropyl groups through post-synthesis. The contribution of large pore sizes and surface chemical groups on DOX loading and release were systemically studied using transmission electron microscope (TEM), nitrogen adsorption/desorption measurement, Fourier transform infrared spectroscopy (FTIR), zeta potential analysis, X-ray photoelectron spectroscopy (XPS) and ultraviolet spectrophotometer (UV). The results demonstrated that the NSNs were functionalized with aminopropyl successfully and the DOX molecules were adsorbed inside the nanopores by the hydrogen bonding. The release performance indicated that DOX loaded M-NSNs significantly controlled DOX release, furthermore DOX loaded M-NSNs-NH performed slower controlled release, which was mainly attributed to its stronger hydrogen bonding forces. As expected, we developed a novel carrier with high drug loading capacity and controlled release for DOX.
本研究的目的是开发负载盐酸多柔比星（DOX）的氨基修饰多模态纳米多孔二氧化硅纳米颗粒（M-NSNs-NH），旨在提高药物负载量并实现控释效果。通过合成后修饰使M-NSNs用氨丙基官能化。使用透射电子显微镜（TEM）、氮吸附/解吸测量、傅里叶变换红外光谱（FTIR）、zeta电位分析、X射线光电子能谱（XPS）和紫外分光光度计（UV）系统研究了大孔径和表面化学基团对DOX负载和释放的影响。结果表明，NSNs成功地用氨丙基官能化，并且DOX分子通过氢键吸附在纳米孔内。释放性能表明，负载DOX的M-NSNs显著控制了DOX的释放，此外，负载DOX的M-NSNs-NH表现出更慢的控释，这主要归因于其更强的氢键作用力。正如预期的那样，我们开发了一种用于DOX的具有高药物负载量和控释功能的新型载体。
