Modified green synthesis of FeO@SiO nanoparticles for pH responsive drug release.

A magnetic field activated drug delivery and pH-sensitive controlled drug release system based on carboxyl-modified green synthesized FeO@SiO (FeO@SiO-Glu) nanoparticles was established. Doxorubicin hydrochloride (DOX), as a drug model, was adsorbed onto the FeO@SiO-Glu nanoparticles' surface, where the observed drug loading capacity of 34.6 mg/g was attributed to electrostatic interaction between -COO on the surface of FeO@SiO-Glu and -NH of DOX. The structure, morphology and physiochemical properties of FeO@SiO-Glu were characterized via TEM, FTIR, XRD, N adsorption/desorption isotherms, and Zeta potential measurements. The green synthesized FeO@SiO-Glu nanoparticles exhibited multilayer architecture with a BET surface area of 79.9 m/g and a magnetization saturation of 25.9 emu/g. Drug release experiments indicated that DOX was pH trigger released with 60.8% released within 72 h at pH 3.5. This system has important potential implications for the design of more effective and stable magnetic FeO@SiO-Glu materials as drug carriers for targeted and controlled drug release.