Ivanov A V, Bobyntsev I I, Shepeleva O M, Kryukov A A, Andreeva L A, Myasoedov N F
Department of Histology, Embryology, and Cytology, Kursk, Russia.
Department of Pathophysiology, Kursk, Russia.
Bull Exp Biol Med. 2017 May;163(1):105-108. doi: 10.1007/s10517-017-3748-4. Epub 2017 Jun 3.
We studied the effect of intraperitoneal administration of peptide ACTG-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.
我们研究了以5、50、150和450μg/kg的剂量向雄性Wistar大鼠腹腔注射肽ACTG-PGP，对慢性情绪和疼痛应激状态下肝细胞形态功能的影响。观察到该肽具有剂量依赖性的应激限制作用：它使肝脏的蛋白质合成功能和血清ALT活性恢复正常。在多核和多核仁细胞相对数量增加以及血清蛋白浓度恢复减慢的背景下，该肽的抗细胞溶解作用随剂量增加而增强。在蛋白质合成过程的形态学迹象更明显的背景下，肝细胞细胞溶解的减少证明通过增强蛋白质的组成性合成激活了肝实质中的修复过程。
