细胞因子在滋养层细胞存在的情况下对内皮细胞形成管状结构的影响。
Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells.
作者信息
Sokolov D I, Lvova T Yu, Okorokova L S, Belyakova K L, Sheveleva A R, Stepanova O I, Mikhailova V A, Sel'kov S A
机构信息
D. O. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg, Russia.
出版信息
Bull Exp Biol Med. 2017 May;163(1):148-158. doi: 10.1007/s10517-017-3756-4. Epub 2017 Jun 3.
Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-γ, IL-10, TNF-α, and TGFβ via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.
尽管关于子宫胎盘界面细胞因子分泌已有大量数据，但微环境细胞，尤其是滋养层细胞对血管生成的影响以及细胞因子在此过程中的作用仍研究不足。我们研究了细胞因子在滋养层细胞存在的情况下对内皮细胞形成管状结构的影响，结果表明滋养层细胞抑制了内皮细胞的血管生成潜能。抗血管生成细胞因子IFN-γ、IL-10、TNF-α和TGFβ通过调节滋养层细胞刺激了内皮细胞形成管状结构。在内皮细胞与滋养层细胞的共培养中，细胞因子的作用发生了变化，它们获得了额外的调节功能。
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