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较低的性激素结合球蛋白（SHBG）水平与较高的瘦素和较低的脂联素水平以及代谢综合征相关，且与睾酮无关。

Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone.

机构信息

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.

出版信息

Sci Rep. 2017 Jun 2;7(1):2727. doi: 10.1038/s41598-017-03078-0.

DOI:10.1038/s41598-017-03078-0
PMID:28577342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5457423/
Abstract

In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in 614 Taiwanese men over 40 years old collected from a free health screening. Subjects in the lowest quartile of TT and SHBG levels are exposed to a 1.58 and 3.22 times risk of developing MetS, as compared to those in the highest quartile of TT and SHBG levels. However, SHBG retains its significance independent of TT as a MetS risk predictor, but not vice versa. In addition, SHBG was significantly correlated with both adiponectin and leptin levels even after adjusting for TT levels. In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.

摘要

除了睾酮（T）之外，近来人们注意到性激素结合球蛋白（SHBG）在代谢综合征（MetS）发病机制中的作用也逐渐显现。然而，关于其与血清脂联素和瘦素水平相关性的报道仍然有限。因此，我们进行了这项研究，以评估在 614 名 40 岁以上的台湾男性中，血清 T 和 SHBG 水平是否与脂联素和瘦素水平相关，是否可作为 MetS 风险的独立预测因子。与 TT 和 SHBG 水平最高四分位数的受试者相比，TT 和 SHBG 水平最低四分位数的受试者发生 MetS 的风险分别增加 1.58 倍和 3.22 倍。然而，SHBG 作为 MetS 风险预测因子的意义独立于 TT，但 TT 却不能反过来预测 SHBG。此外，即使在调整 TT 水平后，SHBG 与脂联素和瘦素水平仍显著相关。总之，SHBG 是 MetS 风险的主要预测因子，与 T 无关，与血清脂联素和瘦素水平相关。需要进一步的研究来阐明 SHBG 在 MetS 发病机制中的真正作用以及与血清脂联素和瘦素水平相关的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0928/5457423/f8a8c990cd08/41598_2017_3078_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0928/5457423/f8a8c990cd08/41598_2017_3078_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0928/5457423/f8a8c990cd08/41598_2017_3078_Fig1_HTML.jpg

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