Heinrichs D W, Cohen B P, Carpenter W T
J Nerv Ment Dis. 1985 Mar;173(3):133-8. doi: 10.1097/00005053-198503000-00001.
Despite maintenance treatment, including the prophylactic use of neuroleptics, there is a significant rate of psychotic relapse and rehospitalization in schizophrenic outpatients. Thus comprehensive aftercare should ideally include clinical strategies of early intervention designed to abort decompensations in their earliest stages before florid psychosis and rehospitalization occur. Factors likely to improve the success rate of such strategies include the presence of a phase of prodromal symptoms preceding florid psychosis during which interventions could be made, as well as the patient's insight at such times that he/she is becoming ill, which would facilitate cooperation with intervention. While there is considerable evidence that a prodromal phase is typically present, there has been little exploration of "early insight." This study examines two hypotheses about early insight: 1) insight is present in a sizable portion of schizophrenic patients in the early phase of relapse; and 2) such early insight predicts a successful resolution of the relapse on an outpatient basis without the need for rehospitalization. In a retrospective research design utilizing clinical progress notes, both hypotheses were corroborated. Of the 38 patients in the sample, 24 (63%) demonstrated early insight, and of these only two (8%) were hospitalized as a result of the relapse. Conversely, seven of 14 (50%) uninsightful patients required rehospitalization (p = .006). This supports the feasibility of an early intervention strategy and confirms that early insight is an important patient attribute that predicts successful implementation of this treatment. Clinical experience in trying to develop early insight in the context of a psychotherapeutic relationship and the implications of early intervention for reducing the overall exposure to neuroleptics in schizophrenic populations are discussed.
尽管进行了维持治疗,包括预防性使用抗精神病药物,但精神分裂症门诊患者的精神病复发率和再次住院率仍然很高。因此,理想的综合后续护理应包括早期干预的临床策略,旨在在明显精神病发作和再次住院之前的最早阶段中止病情恶化。可能提高此类策略成功率的因素包括:在明显精神病发作之前存在前驱症状阶段,在此期间可以进行干预;以及患者在此时对自己正在患病的洞察力,这将有助于配合干预。虽然有大量证据表明通常存在前驱期,但对“早期洞察力”的探索却很少。本研究检验了关于早期洞察力的两个假设:1)在复发早期的相当一部分精神分裂症患者中存在洞察力;2)这种早期洞察力预示着门诊患者的复发能够成功解决,无需再次住院。在一项利用临床进展记录的回顾性研究设计中,两个假设均得到了证实。在样本中的38名患者中,24名(63%)表现出早期洞察力,其中只有两名(8%)因复发而住院。相反,14名无洞察力患者中有7名(50%)需要再次住院(p = 0.006)。这支持了早期干预策略的可行性,并证实早期洞察力是预测该治疗成功实施的重要患者特征。本文还讨论了在心理治疗关系中培养早期洞察力的临床经验以及早期干预对减少精神分裂症患者总体抗精神病药物暴露的影响。