Divaris Kimon
Department of Pediatric Dentistry, UNC School of Dentistry, University of North Carolina at Chapel Hill, 228 Brauer Hall, CB#7450, Chapel Hill, NC 27599, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, CB #7435, Chapel Hill, NC 27599, USA.
Dent Clin North Am. 2017 Jul;61(3):619-625. doi: 10.1016/j.cden.2017.02.008. Epub 2017 May 8.
Pediatric oral health is determined by the interaction of environmental factors and genetic influences. This is the case for early childhood caries, the most common disease of childhood. The complexity of exogenous-environmental factors interacting with innate biological predispositions results in a continuum of normal variation, as well as oral health and disease outcomes. Optimal oral health and care or precision dentistry warrants comprehensive understanding of these influences and tools enabling intervention on modifiable factors. This article reviews the current knowledge of the genomic basis of pediatric oral health and highlights known and postulated mechanistic pathways of action relevant to early childhood caries.
儿童口腔健康取决于环境因素与遗传影响之间的相互作用。幼儿龋齿这种儿童最常见的疾病便是如此。外源性环境因素与先天生物易感性相互作用的复杂性导致了正常变异的连续体，以及口腔健康和疾病结果。最佳的口腔健康与护理或精准牙科需要全面了解这些影响因素以及能够对可改变因素进行干预的工具。本文综述了儿童口腔健康基因组基础的当前知识，并强调了与幼儿龋齿相关的已知和推测的作用机制途径。
