Poddar Sourav K, Widstrom Luke
Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Clin Sports Med. 2017 Jul;36(3):447-456. doi: 10.1016/j.csm.2017.02.003. Epub 2017 Apr 22.
Nonoperative options for articular cartilage injury are pervasive but have not shown to be curative. Recommendations for low-impact exercise and weight loss provide benefit and are a foundation for the treatment of osteoarthritis. Judicious use of NSAIDs and acetaminophen can be appropriate for pain management. Topical NSAIDs may be a treatment option with fewer side effects than its oral counterpart. Additionally, viscosupplementation injections are useful for mild to moderate knee osteoarthritis, whereas short-term pain relief is provided by intra-articular corticosteroid injections. Future studies to individualize treatment options based on patient phenotype and genotype may hold promise.
关节软骨损伤的非手术治疗方法很普遍，但尚未显示出能治愈的效果。低冲击运动和减肥的建议有益，是骨关节炎治疗的基础。谨慎使用非甾体抗炎药（NSAIDs）和对乙酰氨基酚可用于疼痛管理。局部使用NSAIDs可能是一种副作用比口服同类药物少的治疗选择。此外，注射透明质酸钠对轻至中度膝关节骨关节炎有用，而关节内注射皮质类固醇可提供短期疼痛缓解。未来基于患者表型和基因型个体化治疗方案的研究可能很有前景。
