Bieber Thomas
Department of Dermatology and Allergy, Christine Kühne-Center for Allergy Research and Education, University Medical Center, Sigmund-Freud-Street 25, Bonn 53127, Germany.
Dermatol Clin. 2017 Jul;35(3):275-281. doi: 10.1016/j.det.2017.02.001. Epub 2017 Apr 14.
Although atopic dermatitis (AD) is the most common skin disorder, there remains an ongoing debate on this denomination, its definition and the binary view based on immunoglobulin E measurement. The wide spectrum of the clinical phenotype of AD reflects the complex genetic and pathophysiologic mechanisms underlying the disease. The diagnostic criteria have to be reconsidered and adapted to different ethnic populations. There is an urgent need for biomarker discovery further supporting the clinical diagnostic criteria as well as the precision medicine approach on a global level.
尽管特应性皮炎（AD）是最常见的皮肤疾病，但关于这一命名、其定义以及基于免疫球蛋白E测量的二元观点仍存在持续的争论。AD临床表型的广泛谱系反映了该疾病潜在的复杂遗传和病理生理机制。诊断标准必须重新审视并适用于不同种族人群。迫切需要发现生物标志物，以在全球范围内进一步支持临床诊断标准以及精准医学方法。
