Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, School of Medicine, Catania, Italy.
Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, School of Medicine, Catania, Italy.
Eur J Pharmacol. 2017 Dec 15;817:51-58. doi: 10.1016/j.ejphar.2017.05.059. Epub 2017 May 31.
Since publication of the results of the Women Health Initiative Memory Study demonstrating that hormone therapy initiated late after menopause increases the risk of dementia in women, attempts have been made to identify a "critical window of intervention". In the meantime, basic research carried out in the last 10-15 years has reinforced the concept of a strong impact of estrogen in neuroprotection, moving also into novel directions that include characterization of estrogen's effect on non-neuronal cells, mitochondrial function, miRNA production and novel targets for their action in the central nervous system (CNS). All these findings, together with a list of recent animal models of Alzheimer's Disease that appear feasible for the study of estrogen's CNS effect are here summarized and accompanied by the most recent data from clinical trials in which hormone therapy was initiated early after menopause.
自妇女健康倡议记忆研究的结果公布以来，该研究表明绝经后晚期开始激素治疗会增加女性痴呆的风险，因此人们试图确定一个“关键干预窗口期”。在此期间，过去 10-15 年进行的基础研究加强了雌激素对神经保护的强烈影响的概念，并进一步提出了雌激素对非神经元细胞、线粒体功能、miRNA 产生和其在中枢神经系统（CNS）中作用的新靶点的影响，所有这些发现，以及最近的阿尔茨海默病动物模型的列表，这些模型似乎适用于研究雌激素对中枢神经系统的影响，都在这里进行了总结，并附有激素治疗在绝经后早期开始的临床试验的最新数据。
