韩国养殖鸭源解脲葡萄球菌复合群多药耐药株 SNUDS-2 的全基因组序列
Complete genome sequence of multidrug-resistant Staphylococcus cohnii ssp. urealyticus strain SNUDS-2 isolated from farmed duck, Republic of Korea.
机构信息
CJ CheilJedang Feed & Livestock Research Institute, Suwon 16495, Republic of Korea.
Biological and Genetic Resources Assessment Division, National Institute of Biological Resources, Incheon 22689, Republic of Korea.
出版信息
J Glob Antimicrob Resist. 2017 Sep;10:37-39. doi: 10.1016/j.jgar.2017.05.008. Epub 2017 Jun 1.
OBJECTIVES
Staphylococcus cohnii has become increasingly recognized as a potential pathogen of clinically significant nosocomial and farm animal infections. This study was designed to determine the genome of a multidrug-resistant S. cohnii subsp. urealyticus strain SNUDS-2 isolated from a farmed duck in Korea.
METHODS
Genomic DNA was sequenced using the PacBio RS II system. The complete genome was annotated and the presence of antimicrobial resistance and virulence genes were identified.
RESULTS
The annotated 2,625,703 bp genome contained various antimicrobial resistance genes conferring resistance to β-lactam, aminoglycosides, fluoroquinolones, phenicols and trimethoprim. The virulence-associated three synergistic hemolysins have been identified in the strain.
CONCLUSIONS
To the best of our knowledge, this is the first complete genome of S. cohnii, and will provide important insights into the biodiversity of CoNS and valuable information for the control of this emerging pathogen.
目的
凝固酶阴性葡萄球菌（CoNS）已被越来越多地认为是临床重要的医院感染和农场动物感染的潜在病原体。本研究旨在确定从韩国养殖鸭中分离的多药耐药性解脲亚种凝固酶阴性葡萄球菌 SNUDS-2 菌株的基因组。
方法
使用 PacBio RS II 系统对基因组 DNA 进行测序。对完整基因组进行注释，并确定存在的抗微生物药物耐药性和毒力基因。
结果
注释的 2625703 bp 基因组包含各种赋予β-内酰胺类、氨基糖苷类、氟喹诺酮类、苯氧青霉素类和甲氧苄啶类抗药性的抗微生物药物耐药性基因。该菌株中鉴定出与毒力相关的三种协同溶血素。
结论
据我们所知，这是凝固酶阴性葡萄球菌的第一个完整基因组，将为 CoNS 的生物多样性提供重要的见解，并为控制这种新兴病原体提供有价值的信息。
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