Reddy Prakash Narayana, Srirama Krupanidhi, Dirisala Vijaya R
Department of Biotechnology, Vignan's University, Guntur, India.
Infect Dis (Auckl). 2017 May 22;10:1179916117703999. doi: 10.1177/1179916117703999. eCollection 2017.
is an important pathogen responsible for a variety of diseases ranging from mild skin and soft tissue infections, food poisoning to highly serious diseases such as osteomyelitis, endocarditis, and toxic shock syndrome. Proper diagnosis of pathogen and virulence factors is important for providing timely intervention in the therapy. Owing to the invasive nature of infections and the limited treatment options due to rampant spread of antibiotic-resistant strains, the trend for development of vaccines and antibody therapy is increasing at rapid rate than development of new antibiotics. In this article, we have discussed elaborately about the host-pathogen interactions, clinical burden due to infections, status of diagnostic tools, and treatment options in terms of prophylaxis and therapy.
是一种重要的病原体，可导致多种疾病，从轻度皮肤和软组织感染、食物中毒到非常严重的疾病，如骨髓炎、心内膜炎和中毒性休克综合征。正确诊断病原体和毒力因子对于在治疗中及时进行干预很重要。由于感染的侵袭性以及抗生素耐药菌株猖獗传播导致治疗选择有限，疫苗和抗体疗法的开发趋势比新抗生素的开发速度更快。在本文中，我们详细讨论了宿主与病原体的相互作用、感染导致的临床负担、诊断工具的现状以及预防和治疗方面的治疗选择。
