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羊栖菜硫酸多糖的抗肿瘤活性

Anti-tumor activity of sulfated polysaccharides from Sargassum fusiforme.

作者信息

Yu Miao, Ji Yubin, Qi Zheng, Cui Di, Xin Guosong, Wang Bing, Cao Yue, Wang Dandan

机构信息

Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China.

Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, China.

出版信息

Saudi Pharm J. 2017 May;25(4):464-468. doi: 10.1016/j.jsps.2017.04.007. Epub 2017 Apr 28.

DOI:10.1016/j.jsps.2017.04.007
PMID:28579876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447403/
Abstract

In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with the chlorosulfonic acid pyridine method. The inhibitory effect of Sargassum fusiforme polysaccharides and the application of MTT assay before and after chemical modification on the proliferation of hepatocellular carcinoma HepG-2 cells in vitro were studied. Sulfated polysaccharide from sargassum fusiforme DS is 0.803. The modified polysaccharide has certain inhibitory effect on HepG-2 cells, and its inhibition on the cells growth has improved compared with the original SFPs. The sulfated polysaccharide from Sargassum fusiforme has the ability to enhance anti-tumor activities.

摘要

在本研究中，我们的目的是发现硫酸化多糖结构与抗肿瘤活性之间的相关性。采用氯磺酸吡啶法合成了羊栖菜硫酸化多糖。研究了羊栖菜多糖及其化学修饰前后MTT法对体外肝癌HepG-2细胞增殖的抑制作用。羊栖菜硫酸化多糖的取代度DS为0.803。修饰后的多糖对HepG-2细胞有一定的抑制作用，与原始羊栖菜多糖相比，其对细胞生长的抑制作用有所提高。羊栖菜硫酸化多糖具有增强抗肿瘤活性的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/9a67acc322e6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/3ce01479f14b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/485d3ae9d226/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/f3ad378fbc84/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/9a11479193df/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/eee63205ce67/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/9a67acc322e6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/3ce01479f14b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/485d3ae9d226/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/f3ad378fbc84/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/9a11479193df/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/eee63205ce67/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b21/5447403/9a67acc322e6/gr6.jpg

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